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OU—Dept. of Chemistry and Biochemistry—Stephenson Life Sciences Research Facility

Antibiotic Discovery and Resistance Group

Dr.Helen Zgurskaya Lab

Contact us: Antibiotic-efflux@outlook.com

t.405-325-1678 | f.405-325-6111

 

 

 

09/05/2014-09/09/2014 | Interscience Conference on Antimicrobial Agents and Chemotherapy. Four posters will be presented. MORE DETAILS>

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11/17/2014-11/19/2014 | International Congress on Bacteriology and Infectious Diseases. Oral Presentation. MORE DETAILS>

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11/17/2014-11/21/2014 | 2014 Chemical and Biological Defense (CBD) Science & Technology Conference. MORE DETAILS>

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03/29/2015-04/02/2015 | Keystone Symposium on Gram-negative Resistance. Oral presentation. MORE DETAILS>

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04/25/2015-05/01/2015 | Gordon Research Seminar and Conference on Multi-drug Efflux Systems. MORE DETAILS>

ABOUT OUR GOALS

“A post-antibiotic era, in which common infections and minor

injuries can kill, far from being an apocalyptic fantasy, is instead a

very real possibility for the 21st century” - WHO 2014

 

Drug resistance presents an ever-increasing threat to public health

and encompasses all major microbial pathogens and antimicrobial

drugs. Some pathogens have acquired resistance to multiple

antibiotics and cause infections that are effectively untreatable.

There is a strong need for new therapeutic options, particularly

those directed against multi-resistant Gram-negative bacteria.

The major factor defining the high intrinsic and acquired multidrug

resistance of Gram-negative pathogens is their low cell wall

permeability. This permeability barrier is created by the synergistic

action of two processes that occur in different membranes of

Gram-negative cell walls. In the outer membrane, an asymmetric

lipid bilayer and narrow pores significantly reduce uptake of both

hydrophilic and hydrophobic compounds. In the inner membrane,

multidrug efflux transporters actively expel a broad range of

antibiotics from the cells.

 

Our research is focused on understanding fundamental principles

that govern permeation of antibiotics into bacterial cells and on

development of novel small molecule therapeutics that potentiate

activities of antibiotics.

Upcoming events tag

2014-2015

FluorescencePumps

Cell envelope of Gram-negative bacteria contains several efflux pumps varying in their composition and mechanism. Three-components pump such as AcrAB-TolC bind substrates in the periplasm and pump them out across the outer membrane (OM). Single component transporters such as MdfA pump substrates across the inner membrane (IM). These pumps act synergistically with low permeability barrier of the outer membrane (OM).

RESEARCH PROJECTS

Mechanism of drug permeation across

Gram-negative cell walls. MORE>

Funding Agency: Defense Threat

Reduction Agency

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Transport across two membranes by

AcrAB-TolC complex. MORE>

Funding Agency: National Institute of

Allergy and Infectious Dise ases